MAPT and Alzheimer disease: Alzheimer’s disease has two specific neuropathological markers: first, extracellular deposition of amyloid-β (Aβ) protein as diffuse and neuritic plaques and, second, dystrophic neurites and intraneuronal neurofibrillary tangles (NFTs) composed of aggregated hyperphosphorylated tau protein (Jack et al., 2018).