Deficits in olfactory behavior were demonstrated in the 3xTg-AD mouse model for human AD, which expresses mutations in PSEN1, APP with the Swedish mutations, and mutated tau, leading to development of Aβ and tau pathologic lesions in a sequential manner (Oddo et al., 2003; Cassano et al., 2011). Here, MAPT is linked to Alzheimer disease.