Because no tau mutations have been found in sporadic AD, mouse models for tau are mainly considered models for dementia (Jankowsky and Zheng, 2017), and tau expression might not recapitulate the evolution of NFTs spreading between synaptically connected regions (Gendron and Petrucelli, 2009; Jankowsky and Zheng, 2017). This evidence concerns the gene MAPT and Alzheimer disease.