FOXC2 and cancer: According to the intensity of IHC staining, no or weak staining of FOXC2 protein was seen in 115 of 280 (41.1%) paraffin-embedded HCC tissues, while moderate staining (in the membrane and cytoplasm of cancer cells) was observed in 104 of 280 (37.1%) samples and strong staining was observed in 61 of 280 (21.8%) samples.