It has been reported that ubiquitin ligase FBXO22 [21] mediates the multiubiquitination and degradation of CD147 by interacting with the intracellular domain CD147-ICD of transmembrane glycoprotein CD147, thus reversing the cisplatin resistance of SMMC-7721, Huh-7 and A549 cancer cells. The gene discussed is FBXO22; the disease is cancer.