FBXO22 and lung adenocarcinoma: To clarify the function of E3s and explore whether they can affect the survival of lung adenocarcinoma patients, we consulted the public database (http://gepia.cancer-pku.cn/) and found that in 42 E3s, E3s including ARPC1A, AURKA, CDC20, CDCA3, CHAF1B, FBXO22, PPP1R13L and TRIP12 were negatively correlated with the prognosis of LUAD patients (Fig. 1b).