To clarify the function of E3s and explore whether they can affect the survival of lung adenocarcinoma patients, we consulted the public database (http://gepia.cancer-pku.cn/) and found that in 42 E3s, E3s including ARPC1A, AURKA, CDC20, CDCA3, CHAF1B, FBXO22, PPP1R13L and TRIP12 were negatively correlated with the prognosis of LUAD patients (Fig. 1b). This evidence concerns the gene ARPC1A and lung adenocarcinoma.