Other epigenetic mechanisms, such as histone modifications, were observed in chronic lung diseases, for example, Cav‐1 expression was suppressed by the histone deacetylase inhibitor, trichostatin A.90Expression of Cav‐1 was downregulated in IPF, when CAV1 was silenced through diminished binding of the active histone mark histone H3 trimethyl Lys4 with its promoter region.91 The gene discussed is CAV1; the disease is chronic lung disease.