Our review aims at overviewing the biological characters, structure and function of Cav‐1, epigenetic modifications of Cav‐1 in health and disease, expression and regulation of Cav‐1 in the respiratory system, Cav‐1 methylation and significance in chronic lung diseases, as well as clinical potential as disease‐specific biomarker and targets for early diagnosis and therapy. Here, CAV1 is linked to chronic lung disease.