In the present study, we aimed to assess TILs (including programmed death‐1 (PD‐1)+, CD3+, CD8+, CD20+, and Foxp3+ lymphocytes, where CD is cluster of differentiation) from the tumoral and stromal subregions of chordoma tissues using multiplexed quantitative immunofluorescence and attempted to establish an immune risk score (IRS) model for outcome prediction. The gene discussed is FOXP3; the disease is chordoma.