David et al identified two distinct CAFs subtypes in PDAC: iCAFs, which lack elevated αSMA expression and instead express inflammatory markers such as IL‐6 and leukemia inhibitory factor and are located farther away from tumor cells; and myofibroblastic CAFs, which express markers of myofibroblasts, such as αSMA, and are found adjacent to tumor cells.47, 48. The gene discussed is ACTA1; the disease is neoplasm.