PCSK9 and hepatocellular carcinoma: For example, the inhibitory roles of acRoots hepatocellular carcinoma (HCC) cell growth depend upon the degree of malignancy, stages of cell cycle, and doses, probably through altering metabolic signaling responses and cancer cell inflammation gene clusters such as prostaglandin E receptor 3 (EP3) or proprotein convertase subtilisin/kexin type 9 (PCSK9).2, 3