Our previous studies evidenced that other factors such as long‐chain acyl‐Co A synthetase, OASL, PCSK9, EP3, retinoic acid receptor, and distal‐less homeobox 2 could also play critical roles in cancer cell sensitivity to acRoots,1, 2, 3, 10, 20 as explained in Figure 8. The gene discussed is PCSK9; the disease is cancer.