Among these molecules, CALR and its exposure, indicating translocation from the endoplasmic reticulum to the cell membrane, play a dominant role in dictating chemotherapy‐induced cancer immunogenic cell death, and anticancer immune response in multiple cancers (eg, melanoma, sarcoma, colorectal carcinoma, and breast cancer).14, 15, 16. The gene discussed is CALR; the disease is colorectal carcinoma.