HMGB1 and familial pancreatic carcinoma: It was observed that although all of the expression levels of ANXA1, HMGB1, IFNAR1, and PANX1 were significantly upregulated in pancreatic cancer (Figure S3A‐D), the high expression of ANXA1, HMGB1, IFNAR1, and PANX1 was either nonsignificant or unfavorable for the OS (Figure S3E‐H) and DFS (Figure S3I‐L) of pancreatic cancer patients.