According to the univariate and multivariate Cox regression analyses results for the OS of CRC patients, all of the significant variables, including race, sex, tumor site, CEA level, grade, age, histological type, tumor size, N stage, LNH, N stage, liver metastases, lung metastases, bone metastases and brain metastases, were integrated to establish the prognostic nomogram for OS (Table 4). This evidence concerns the gene CEACAM5 and neoplasm.