Based on CD24's inhibition of macrophage function in the context of cancer and the inhibitory signaling mediated via Siglec‐10/G that can occur in DC, it will be important going forward to explore how the CD24/Siglec‐10/G axis might disrupt DC function within the TME, as this pathway might also serve as a significant barrier to the induction and/or maintenance of antitumor T cell responses by DC. The gene discussed is SIGLEC10; the disease is cancer.