Although the antitumor activity of 2B4 blockade has yet to be investigated, blockade of this checkpoint receptor does improve overall T cell effector function and survival in an animal model of sepsis with preexisting malignancy,221 and blockade of either CD48 or 2B4 reverses CD8+ T cell exhaustion in the context of chronic viral infection.222, 223. Here, CD244 is linked to Sepsis.