On the other hand, in CD8+ TIL from renal cell carcinoma patients, reduced glucose uptake was associated not with reduced expression of GLUT1 but instead with a loss of phosphorylation of this transporter, a phenomenon that authors attributed to a probable failure of dephosphorylated GLUT1 to traffic to the cell surface.243. The gene discussed is CD8A; the disease is renal cell carcinoma.