Extracellular ATP itself is frequently elevated in the TME,102 and while its release from tumor cells can promote immunogenic signaling as a DAMP through purinergic receptors on DC,103 it is often converted into adenosine by the ectonucleotidases CD39 and CD73,104, 105 leading instead to immunosuppressive signaling through A2A and A2B adenosine receptors on various immune cell populations. The gene discussed is ENTPD1; the disease is neoplasm.