Though these expanded CD8+ T cells retain expression of cell surface markers indicative of exhaustion, likely due to epigenetic maintenance of co‐inhibitory molecule expression,150 the accumulation of less exhausted non‐terminally differentiated (PD‐1+ TIM3low TBET+ EOMES−) and fully exhausted terminally differentiated (PD‐1high TIM3+ TBET+ EOMES+) CD8+ T cells is associated with improved tumor control. The gene discussed is CD8A; the disease is neoplasm.