Importantly, this and a related study highlighted several interventions that could improve antitumor immune function by interfering with cholesterol metabolism or its downstream effects, including treatment of tumor‐bearing mice with an ER stress inhibitor, adoptive transfer of XBP1‐knockdown tumor‐specific CD8+ T cells, treatment of CD8+ T cells with β‐cyclodextrin to deplete cholesterol prior to adoptive transfer, and pharmacologic reduction of cholesterol content in the TME.262, 263. This evidence concerns the gene XBP1 and neoplasm.