In this regard, it is worth noting that Bat3 gene expression is significantly reduced in exhausted TIM‐3+ TIL isolated from murine mammary adenocarcinomas174 and that the long noncoding RNA lnc‐Tim3 binds to TIM‐3′s cytoplasmic tail and promotes release of Bat3 in exhausted CD8+ TIL from hepatocellular carcinoma patients.175. This evidence concerns the gene HAVCR2 and hepatocellular carcinoma.