We found that the positive rate of OX40 was similar between each tumor subregion and their corresponding IM (HCC: 42.9% vs HCC‐IM: 48.2%, P = .285; ICC: 35.7% vs ICC‐IM: 39.3%, P = .789), but lower in the peritumor liver (14.3%). This evidence concerns the gene TNFRSF4 and hepatocellular carcinoma.