Recently, increased S‐nitrosylation of muscle LIM protein (MLP) in pressure‐overloaded HF was reported to induce the formation of a complex between Toll‐like receptor 3 (TLR3) and receptor‐interacting protein kinase 3 (RIP3), thereby activating NLRP3 inflammasome and promoting the progression of myocardial hypertrophy.54 Here, NLRP3 is linked to cardiac hypertrophy.