IL10 and melanoma: However, our current 3D RhS-Mel model does allow for near-physiological cross-talk events between the keratinocyte/fibroblast/melanoma cell triad, thus enabling the study of the involvement of a myriad of secreted factors in the TME (e.g. IL-10) which are involved in melanoma-imposed immune suppression and which would otherwise have been missed in classic 2D melanoma cell line cultures.