To determine if expression of human ZSCAN4 leads to similar epigenetic changes in cancer cells, we examined a panel of acetylation patterns of Histone 3 Lysine residues 9, 14, 18, and 27 (H3K9ac, H3K14ac, H3K18ac, and H3K27ac) after ZSCAN4 induction. The gene discussed is ZSCAN4; the disease is cancer.