The qPCR result of a small-sample study (10 cases) showed that the expression level of CD109 mRNA was higher in cervical squamous cell carcinoma than normal tissue and endometrial adenocarcinoma.5 We here present the first report of a large-sample IHC analysis of two cervical TMAs, which demonstrated the expression of CD109 in cervical tissues at protein level. Here, CD109 is linked to cervical squamous cell carcinoma.