PGR and metastatic malignant neoplasm in the lymph nodes: Expression levels of oestrogen receptor (ER) and progesterone receptor (PR), as determined by immunohistochemical (IHC) staining, are established prognostic markers for EC: loss of these receptors is associated with increased risk of lymph node metastasis and recurrence.5,8 ER and PR belong to the steroid receptor family and act as ligand-activated transcription factors for oestrogen and progesterone, respectively.