Co-culture of BV2 microglial cells with OM-MSCs treated with FG-4592 plus hypoxia markedly accelerated the reduction of IL-1β and IL-18 levels in BV2 microglial cells exposed to OGD/R for 12 hours, accompany with the reduction of LDH activity (Figure 8C–8E). The gene discussed is IL1B; the disease is ocular melanoma.