HAVCR1 and renal fibrosis: Compared to the control ZLRs group that received saline, the ZDFRs saline group exhibited renal fibrosis in the tubulointerstitial area observed by Masson’s trichrome (MT) staining, and increased protein levels of anti-kidney injury molecule-1 (Kim-1) evaluated by immunohistochemistry (IHC) (Figure 1A).