To further determine the mechanism underlying of F2R on glioma, we performed GSEA analysis based on the TCGA dataset of GBM, and found MYC targets and Wnt β-catenin signaling pathway were associated with F2R high expression (Figure 7A), as shown by gene sets of HALLMARK_MYC_TARGETS_V1, HALLMARK_WNT_BETA_CATENIN_SIGNALING, WILLERTWNT SIGNALING, DANG_BOUND_BY_MYC. The gene discussed is MYC; the disease is central nervous system cancer.