F2R and glioma: Collectively, the results of the present study showed that F2R promoted malignancy and facilitated metastasis in glioma cells under the regulation of transcription factor SOX2 and triggering Wnt/β-catenin signaling pathway activation, suggesting F2R and its associated pathway is crucial for glioma tumorigenesis, and targeting this pathway may be pivotal in the treatment of glioma.