The findings of this study were as follows: miR-34-5p had cardio-protective effect and could attenuate cardiac fibrosis by targeting ROCK1 pathway; lncRNA SNHG7 was upregulated in mice at 4 weeks after MI; overexpression of SNHG7 inhibited expression of miR-34-5p and promoted proliferation and fibroblast-to-myofibroblast transition and silencing of SNHG7 abolished cardiac remodeling and improved cardiac function. The gene discussed is ROCK1; the disease is myocardial infarction.