All three isotypes of aCL and ofaβ2GPI (IgG, IgM and IgA) were measured by a standardised method andcut-offs for ‘positivity’ were in agreement with the most recent APS classificationcriteria.10,36 Moreover, characterisation of the glycaemic state was extensiveand based on a standardised OGTT. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.