This is in line with previous reports that aPL of the IgG isotypeseems more associated to the pathogenicity of occlusive vascular events than IgM andIgA.28, , –31 Furthermore, type 1 diabeteswas excluded and only IGT and type 2 diabetes were included, in order to selectivelyaccounting for alteration possibly related for a atherothrombotic phenotypeassociated to insulin resistance.6 This evidence concerns the gene CD40LG and Insulin resistance.