MTTP and aortic stenosis: In fact, previous preclinical studies on AVD in animal models have shown other potential treatments for the disease, for example, by lowering plasma cholesterol with the use of statins39,40 or by genetic inactivation of the mttp gene.41 However, those results did not translate into reduced aortic stenosis progression in clinical trials.42–44 It should also be noted that the models used here did not attain Vmax equivalent to human severe AVS.