The immune infiltrate is comprised of innate and adaptive immune cells, whose populations are heterogeneous across tumor types and patients and include nonspecific immune cell types, such as macrophages, neutrophil granulocytes, dendritic, mast and natural killer (NK) cells, or effector cells of specific immunity, like B‐ and CD3+ T cells (CD4+ T helper, CD8+ cytotoxic T, and regulatory T [Treg] cells), localized in tumor nests, or adjacent tumor stroma [11]. Here, CD4 is linked to neoplasm.