Taken a glance in the BENEFIT study, the lung adenocarcinoma patients with concurrent mutations in EGFR and other oncogenes, including KRAS, had significantly shorter PFS than those with EGFR mutations only (13.2 months VS 4·7 months, HR 2.66, 95% CI 1.58–4.49; p = 0.0003) [11]. Here, EGFR is linked to lung adenocarcinoma.