By combining ex vivo and in vitro studies, we report here morphological, biochemical, and electrophysiological correlates of reduced dendritic and synaptic plasticity in the CA1 region of the hippocampus and dentate gyrus in a model of IFN-α and TLR3 activation-induced depression in mice which we previously characterized on the behavioral level [4]. Here, TLR3 is linked to depressive disorder.