PIM1 and large cell neuroendocrine carcinoma: Similarly, mRNA expression of PIM1 was also significantly higher (p < 0.001) in SCLC samples (RQ 2.16 (1.81–3.23)) compared with other BP-NEN groups (RQ 0.85 (0.41–1.26), 0.65 (0.52–0.77), and 1.1 (0.79–1.45), for TC, AC, and LCNEC, respectively) (Fig. 1b).