In contrast, PIM3 mRNA levels were significantly higher (p = 0.048) in TC and AC (RQ 3.58 (1.74–4.32) and 3.93 (2.70–4.68), respectively) than in the aggressive BP-NEN tumors (RQ 1.81 (1.10–2.87) for LCNEC and RQ 2.32 (1.88–2.52) for SCLC) (Fig. 1c). This evidence concerns the gene PIM3 and large cell neuroendocrine carcinoma.