We evaluated the role of JLP in the renal fibrosis regulation based on in vivo studies on unilateral ureteral obstruction (UUO) challenged mice with jlp global or TEC-specific deficiency, or with jlp TEC-specific transgenic overexpression and CKD patients undertaken renal biopsy, and in vitro study on cultured TECs. Here, SPAG9 is linked to renal fibrosis.