KMT2A and neoplasm: We sequenced each tumor sample on a single flow cell and identified, as expected, an EWSR1-FLI1 fusion (ES1, 8 reads) (Supplementary Data 1 and Supplementary Figs. 3A and 4A), a PAX3-FOXO1 fusion (RH, 32 reads) (Fig. 4a, d), a BCR-ABL1 fusion within the major-cluster (CML, 22 reads) (Fig. 4b, d), a translocation between MYC and the IGH locus (BL, 3 reads) (Fig. 4d and Supplementary Fig. 4B), a BCR-ABL1 fusion within the minor-cluster (ALL1, 27 reads) (Fig. 4d and Supplementary Fig. 4C) and a CRLF2-P2RY8 rearrangement (ALL2, 185 reads) (Fig. 4c, d).