As Burkitt’s Lymphoma (BL) is a classic human MYC-associated lymphoma, we measured signaling changes by Phospho-CyTOF before (MYCON) and after (MYCOFF) MYC inactivation in an EBV-transformed human B-cell line that expresses MYC regulated by the Tet System (P493-6), and mimics BL41. Here, MYC is linked to lymphoma.