Tumor-intrinsic signaling changes post MYC inactivation in our T-lymphoma line derived from SRα-tTA/tet-O-MYC mice (Supplementary Fig. 21) mirrored those observed in the human BL-like model with MYC inactivation leading to activation of STAT1/2-Type I IFN signaling (Supplementary Figs. 22 and, 23). Here, MYC is linked to neoplasm.