IL17A and systemic lupus erythematosus: Consistently, the Lyz2cre+Tgfb1fl/fl B6.lpr mice also displayed other enhanced manifestations of lupus characteristics including higher sera titers of both IL-17 and dsDNA antibodies, earlier appearance of proteinuria, more intrarenal lymphocyte infiltration and IgG-containing immune complex deposition in the glomeruli even though the marginal zone barriers are intact (Fig. 5j, k; Supplementary Figs. 14–18).