FOXF2 and cancer: The function of FOXF2 is to act as a master transcription factor and as a regulator of the epithelial-to-osteomimicry transition to make cancer cells metastasize to bone through pleiotropic transactivation of the BMP/SMAD signalling pathway and of BRGs that are expressed at early stages of bone differentiation; these changes lead to osteolytic bone lesions in bone metastasis43.