BRAF and metastatic melanoma: Previous studies have demonstrated a survival benefit with ipilimumab for patients with metastatic melanoma at the 10 mg/kg dose.3 10 Our initial phase III trial involving patients with advanced melanoma who had not received a prior BRAF or checkpoint inhibitor showed significantly longer OS with ipilimumab at 10 mg/kg than at 3 mg/kg, although with an increased incidence of adverse events (AEs).11 Here, we report a 5-year update of this trial, along with updated analyses of specific patient subgroups of clinical relevance.