The decreased severity of bm12 cGVHD when Ezh2 genetically deleted in donor T cells and previous observations that Ezh2 is upregulated in GC T and B cells [10, 23] suggested that pharmacological inhibition of Ezh2 might suppress lupus-like features of bm12 cGVHD. Here, EZH2 is linked to systemic lupus erythematosus.