To investigate whether lncRNA-FMR6 is involved in the development of fragile X-associated premature ovarian insufficiency (FXPOI), 22 consecutive fragile X mental retardation 1 (FMR1) premutation carriers undergoing IVF and pre-implantation genetic diagnosis (IVF-PGD) were studied. Here, FMR1 is linked to premature menopause.