Only a few biomarkers were found to have a role specifically related to sepsis pathophysiology rather than to a more general inflammatory reaction, including presepsin (the N-terminal fragment of the macrophage lipopolysaccharide [LPS] receptor), LPS-binding protein (LBP), bactericidal/permeability increasing protein, peptidoglycan, thrombomodulin, and anti-endotoxin core antibodies. The gene discussed is THBD; the disease is Sepsis.