Similarly, TNFR2 levels were significantly upregulated within 8 h of the vascular event in ischemic stroke patients (413.8 pg/ml [251.3;7090]) compared to controls (276.7 pg/ml [236.7;357.8]) (*p = 0.04) (Fig. 3s). Here, TNFRSF1B is linked to ischemic stroke.