Higher level of IFN-γ in the liver and serum in the TLR4+IFN-γ-activated MSC group indicated clear Th1 dominance in this group which partially underpinned the alleviated histological pathogenesis, and by contrast, still Th2 dominance in the unpretreated MSC group showed no clear improvement of hepatic fibrosis. This evidence concerns the gene TLR4 and Hepatic fibrosis.