The similar trend was observed in terms of fibrosis development, and the TLR4-activated MSC group demonstrated the mildest fibrosis shown by Masson staining and the lowest quantity of hydroxyproline per gram of the liver tissue compared with other infected groups (infected control 198.36 ± 22.63, MSC 202.32 ± 27.68, TLR2-activated MSC 192.78 ± 32.02, and TLR4-activated MSC 144.82 ± 18.22) at 8 weeks post-infection (Fig. 1C1, C3). This evidence concerns the gene TLR4 and infection.