CXCR3 and neoplasm: Previous studies have shown that CXCR3 is expressed on both tumor cells and stromal cells [43, 44]; therefore, we analyzed the distribution of CXCR3-positive cells in CRC tissues via immunofluorescence and found that cells highly expressing CXCR3 were predominantly located in stromal cells rather than in tumor cells (Supplementary Figure 6A, B).