Overall, our findings support a model wherein Th17 cells inhibit the expression of CXCR3 on CD8+ T cells in blood circulation by secreting IL-17A, which activates STAT3 signaling and downregulates CD8+ T cell infiltration in tumor tissues; these effects can be attenuated via Stattic (Fig. 7f). Here, CXCR3 is linked to neoplasm.