CYP3A4 and B-cell chronic lymphocytic leukemia: al. studied the impact of erythromycin and voriconazole and moderate and strong CYP3A inhibitor prototypes respectively, on the pharmacokinetics of 140 mg of ibrutinib, in the context of a multicenter phase I study in 26 patients with low grade B cell malignancies including 14 patients with CLL (53.8%) [21].