There are several options available to help mitigate the risk of a suboptimal response to a GnRH-a trigger, including: using an hCG trigger only for patients at low risk of OHSS; considering a “rescue trigger” using hCG if post-trigger bloodwork reveals a suboptimal response; or using a combination of a GnRH-a trigger with a low dose of hCG, commonly referred to as a “dual trigger”. Here, GNRH1 is linked to ovarian hyperstimulation syndrome.