EV-miR-186 from NK cells induces cytotoxicity to MYCN-amplified neuroblastoma cells; targeted delivery of miR-186 suppresses tumor growth and improves the survival of a orthotopic mouse model of neuroblastoma by targeting MYCN, AURKA, TGFΒR1 and TGFΒR2 [250]. The gene discussed is TGFBR1; the disease is neuroblastoma.