Following our pipeline and mutation prioritization, we identified six SNPs in genes (ZBTB7A, CHD4, HBB, PGLYRP1, MBD3 and MYB) with functional impact (Table 2 and Supplementary File: Table S2) in both data generated from the SCD patients with high and low HbF levels. Here, HBB is linked to Schnyder corneal dystrophy.