The present study suggested that the levels of IL-1β, IL-6 and IL-17 was obviously increased in CFA -induced arthritic rats, and administration of MOIG could markedly and dose-dependently decrease their levels in serum of CFA -induced arthritic rats, indicating that MOIG attenuated the symptom of RA by reducing the inflammatory cytokine level [29, 30]. This evidence concerns the gene IL6 and rheumatoid arthritis.