NPY and cardiac hypertrophy: The rat model of aortic constriction was established to induce myocardial metabolic disorder within 7 days, and it was found that trimetazidine pretreatment could improve the myocardial energy metabolism by reducing serum levels of oxidative stress markers, attenuating the induction of genes related to myocardial hypertrophy, inhibiting the up-regulation of serum neuropeptide Y (NPY) levels, and further increasing the expression of myocardial NPY receptors [27].