Notably, OCT4A and OCT4Bv transcripts were not detected in mesothelial tumour cell lines (MSTO-211H and H2052), a non-malignant mesothelial cell line (Met-5A), or an aggressive large-cell lung cancer line (H1299) that is p53-null [31]. The gene discussed is TP53; the disease is lung large cell carcinoma.