However, the currently presented inverse correlation of low primary tumour PSMA expression ≤10% as independent predictor of shortened RFS (HR 3.0; 95% CI 1.1–8.5; p = .04) has also been described in other cancer types and might partly be explained by epigenetic silencing of the PSMA gene upon tumour progression [27]. The gene discussed is FOLH1; the disease is cancer.