MTDH and migraine disorder: However, the relation between MTDH and migraine remains controversial, also because the SNP did not show significance in subsequent meta-analyses of GWAS data, neither in studies that investigated association with migraine (p = 5 × 10− 3 [16], p = 0.12 [17]) nor migraine with aura (both when the cohorts used to identify the locus were included (p = 1.49 × 10− 4) or excluded (p = 0.59) [17]).