COL4A1 and migraine disorder: Patients with specific mutations in COL4A1 also appear to have an increased prevalence of migraine with aura, in addition to clinical features such as porencephaly type 1, brain small vessel disease with or without ocular anomalies, non-syndromic autosomal dominant congenital cataract, hereditary angiopathy with nephropathy, aneurysms, muscle cramps syndrome, and/or tortuosity of retinal arteries [48–50].