Whereas seven loci (i.e. near TSPAN2, TRPM8, PHACTR1, FHL5, ASTN2, near FGF6, and LRP1) were associated with migraine without aura (in a sample of 8348 cases and 139,622 controls), none were associated with migraine with aura (6332 cases vs. 144,883 controls) [16]. This evidence concerns the gene LRP1 and migraine disorder.