Figure 4 and Supplementary Figure S7 show that individual knockdowns of S100A8, S100A9, and LGALS3BP significantly reduced the formation of tumor-initiating (TI) spheres in all three pancreatic cancer cell lines, i.e., L3.6sl (Figure 4), L3.6pl (Figure 4), and Panc1 (Supplementary Figure S7). Here, S100A8 is linked to familial pancreatic carcinoma.