S100A8 and familial pancreatic carcinoma: To corroborate the biological function of the three candidate TIC genes/proteins, we performed RNAi perturbation experiments by lentiviral shRNA knockdown of S100A8, S100A9, and LGALS3BP in the human pancreatic cancer cell lines L3.6sl and L3.6pl and, for validation, also in KRAS-mutated Panc1 cells.