Figure 4 and Supplementary Figure S7 show that individual knockdowns of S100A8, S100A9, and LGALS3BP significantly reduced the formation of tumor-initiating (TI) spheres in all three pancreatic cancer cell lines, i.e., L3.6sl (Figure 4), L3.6pl (Figure 4), and Panc1 (Supplementary Figure S7). This evidence concerns the gene LGALS3BP and familial pancreatic carcinoma.