The deregulated AGO-gene expression is observed in a variety of malignancies such as breast cancer, melanoma, ovarian, urothelial, prostate, clear-cell renal, gastric, and colorectal carcinomas, as it seems to affect the proliferation rate and/or migratory potential of tumor cells [126,127,128,129,130,131,132]. Here, FBXW7 is linked to melanoma.