AGO2 and obesity due to melanocortin 4 receptor deficiency: Hepatic AGO2 can also regulate the energy expenditure during the course of obesity by RNA silencing through the expression of a subset of miRNAs, including miR-802, miR-103/107, and miR-148a that target the HNF1β, CAV1, and AMPKA1 genes, whose products are critically implicated in glucose and lipid metabolism and homeostasis.