In addition to its anti-hypertensive actions, 500 mg/day (approximately 6 mg/kg/day) of resveratrol supplemented for 30 days improved circulating cholesterol levels and oxidative stress concomitant with upregulated Sirt1 and peroxisome proliferator-activated receptor-gamma (PPARγ) expression in peripheral blood mononuclear cells (PBMCs) in type 2 diabetic patients with coronary artery disease [56]. This evidence concerns the gene PPARG and coronary artery disorder.